… anticancer effect and reduced toxicity of doxorubicin in combination with thymoquinone released from poly-N-acetyl glucosamine nanomatrix in mice bearing solid …

NE El-Ashmawy, EG Khedr, EZM Ebeid… - European Journal of …, 2017 - Elsevier
… (IL-12) loaded into F2 gel is equivalent to the expected activity of multiple doses of free IL-12
Hence, our results proved the ability of F2 gel matrix to release low but significant doses of …

Brief in vitro IL-12 conditioning of CD8 + T Cells for anticancer adoptive T cell therapy

ML Salem, S Salman, IO Barnawi - Cancer Immunology, Immunotherapy, 2021 - Springer
… have also been shown in a variety of infectious diseases, … F2 gel matrix) composed of
poly-N-acetyl glucosamine that … Cytokines are crucial immunomodulatory agents that directly …

F2 Gel Matrix a Novel Delivery System for Immune and Gene Vaccinations

MJ Tuorkey - Asian Pacific Journal of Cancer Prevention, 2016 - journal.waocp.org
… Using polyN-acetyl glucosamine gel matrix to deliver IL-12 with anti- … from polyN-acetyl
glucosamine gel matrix during schistosomiasis infection. Cytotechnol, 66, 667-75; Vournakis JN, …

Loading of doxorubicin and thymoquinone with F2 gel nanofibers improves the antitumor activity and ameliorates doxorubicin-associated nephrotoxicity

AAA Zidan, NE El-Ashmawy, EG Khedr, EZM Ebeid… - Life sciences, 2018 - Elsevier
… of poly-N-acetyl glucosamine (pGlcNAc), which is known as F2 … -12 (IL-12) incorporated
with F2 gel is comparable to the … the traditional praziquantil in treating schistosomiasis [11]. …

Higher Activities of Hepatic Versus Splenic CD8+ T Cells in Responses to Adoptive T Cell Therapy and Vaccination of B6 Mice with MHC Class-1 Binding Antigen

ML Salem, RE El Naggar, SA El Naggar… - Iranian Journal of …, 2017 - ijaai.tums.ac.ir
… Using poly-N-acetyl glucosamine gel matrix to deliver IL-12 with antischistosomasis …
from polyN-acetyl glucosamine gel matrix during schistosomiasis infection. Cytotechnology …

Advances in engineering and delivery strategies for cytokine immunotherapy

M Bohmer, Y Xue, K Jankovic… - Expert Opinion on Drug …, 2023 - Taylor & Francis
… , IL-12 was loaded into an F2 gel matrix (made of polysaccharide polymer poly-N-acetyl
glucosamine… as an adjuvant for a schistosomiasis vaccine (soluble worm antigen preparation) in …

Innate-Like T Cells in Systemic Methicillin-Resistant Staphylococcus aureus Infection

S Genardi - 2021 - search.proquest.com
… T cells produced CD1d independent IL-12 dependent IFN-γ to … polysaccharide and
poly-N-acetyl glucosamine inhibited SA … Trypanosome cruzi and Schistosoma mansoni infection, …